General antonyms:
* Energetic
* Vigorous
* Active
* Lively
* Spirited
* Alert
* Animated
More specific antonyms:
* Dynamic (if referring to energy or dynamism)
* Enthusiastic (if referring to lack of enthusiasm)
* Motivated (if referring to lack of motivation)
* Alert (if referring to drowsiness or sluggishness)
The best antonym will depend on the specific situation and what aspect of "lethargic" you want to emphasize.