General:
* Triumphing over adversity
* Surmounting challenges
* Conquering difficulties
* Overcoming hardships
* Breaking through barriers
* Rising above obstacles
* Navigating difficulties
More specific:
* Persevering (emphasizes determination)
* Resilience (emphasizes ability to bounce back)
* Adaptability (emphasizes adjusting to changes)
* Resourcefulness (emphasizes finding solutions)
* Tenacity (emphasizes strong will)
* Determination (emphasizes strong resolve)
Figurative:
* Breaking new ground
* Charting a new course
* Reaching new heights
The best synonym will depend on the context of your writing.