General Tiredness and Lack of Energy:
* Fatigue
* Exhaustion
* Weariness
* Lassitude
* Listlessness
* Enervation
* Debilitation
* Languor
Sluggishness and Slowness:
* Inactivity
* Torpor
* Dullness
* Apathy
* Indolence
* Sluggishness
* Phlegm
* Heaviness
Mental Slowness:
* Drowsiness
* Stupor
* Somnolence
* Dullness
* Fogginess
* Cloudiness
More Formal or Medical:
* Malaise
* Adynamia
* Asthenia
Informal:
* Dead tired
* Busted
* Drained
* Run down
The best synonym to use will depend on the specific context and the desired level of formality.