General Antonyms:
* Most diligent
* Most hardworking
* Most industrious
* Most energetic
* Most motivated
More Specific Antonyms:
* Most active (if referring to physical activity)
* Most eager (if referring to enthusiasm)
* Most ambitious (if referring to drive)
* Most productive (if referring to output)
The best antonym will depend on the specific meaning of "laziest" in the sentence.