General Antonyms:
* Mislead: To lead someone astray or give incorrect directions.
* Confuse: To make someone uncertain or unable to understand.
* Deceive: To trick or mislead someone intentionally.
* Obstruct: To hinder or block someone's progress.
* Abandon: To leave someone or something behind.
* Ignore: To pay no attention to something.
Specific Antonyms:
* Ignore: (If "guide" means to pay attention to)
* Misdirect: (If "guide" means to direct someone)
* Misinterpret: (If "guide" means to explain something)
* Disregard: (If "guide" means to follow a rule)
* Contradict: (If "guide" means to provide information)
The best antonym depends on the specific meaning of "guide" in the context you're considering.