What is another word for trouble?

Here are some words that can be used instead of "trouble," depending on the context:

General:

* Difficulty

* Problem

* Issue

* Predicament

* Hardship

* Distress

* Mishap

* Setback

* Crisis

Informal:

* Hassle

* Mess

* Fix

* Jam

* Headache

* Bother

More specific:

* Legal: Charge, offense, accusation

* Financial: Debt, hardship, strain

* Physical: Pain, injury, illness

* Emotional: Grief, worry, anxiety

For a more specific suggestion, please provide me with some context!