Neutral:
* Recluse
* Solitary
* Hermit
* Introvert
* Independent
* Self-sufficient
Negative:
* Outcast
* Misanthrope
* Alienated
* Isolated
* Withdrawn
* Unfriendly
Positive:
* Independent
* Self-reliant
* Autonomous
* Individualistic
* Private
The best synonym to use will depend on the context. For example, if you are talking about someone who enjoys spending time alone, "introvert" or "solitary" might be appropriate. If you are talking about someone who is rejected by others, "outcast" or "alienated" might be more fitting.