Simple:
* The book's message left a profound impact on me.
* The philosopher's ideas were profound and thought-provoking.
* The painting evoked a profound sense of peace.
More complex:
* His loss brought a profound sense of sadness to the entire community.
* The scientists made a profound discovery that changed our understanding of the universe.
* The music's profound beauty moved the audience to tears.
* Despite her young age, she possessed a profound understanding of human nature.
Figurative:
* The silence in the room was profound, broken only by the ticking of the clock.
* The doctor looked at the patient with a profound sadness, knowing there was nothing more he could do.
You can also use "profound" to describe a person:
* He was a profound thinker, always questioning the world around him.
* Her words were simple, yet they held a profound wisdom.
The key to using "profound" effectively is to ensure it conveys a sense of depth, intensity, or significance.