* Simple: "The family suffered a series of misfortunes, including a house fire and a job loss."
* Figurative: "His artistic talent seemed cursed by misfortune, with every project meeting some obstacle."
* Emphasizing a specific type of misfortune: "A terrible misfortune befell the town when the storm wiped out their crops."
* With a positive spin: "Despite the misfortune of losing her job, she found a new opportunity that was even better."
* In a literary context: "He felt a surge of pity for the young man, whose life had been marred by misfortune from the very beginning."
Remember that "misfortune" generally refers to something negative or unlucky.