General:
* Wretchedness
* Suffering
* Distress
* Despair
* Agony
* Pain
* Hardship
* Misfortune
* Unhappiness
* Sorrow
More Specific:
* Anguish (intense mental or physical suffering)
* Torment (severe physical or mental suffering)
* Woe (great sorrow or distress)
* Despondency (a state of low spirits from loss of hope or courage)
* Dejection (low spirits from loss of hope or courage)
* Plight (a dangerous, difficult, or unfortunate situation)
* Affliction (something that causes pain or suffering)
The best synonym to use depends on the context and the specific type of misery you want to convey.