It's a playful and informal word that suggests a state of being thrown off balance, both physically and mentally.
Here are some ways to use it:
* "I'm so discombobulated after that meeting. I don't even know what just happened." (Confused and disoriented)
* "The sudden change in plans left me completely discombobulated." (Upset and thrown off)
* "The loud music and flashing lights had a discombobulating effect on the crowd." (Disoriented and confused)
Think of it as someone who's had their internal compass shaken up!