For describing something negative:
* Dreadfully
* Horribly
* Awfully
* Shockingly
* Appallingly
* Desperately
* Miserably
* Excruciatingly
* Catastrophically
* Disastrously
* Abysmally
For expressing a high degree of something:
* Extremely
* Immensely
* Hugely
* Very
* Greatly
* Incredibly
For expressing a negative feeling:
* Sadly
* Regretfully
* Unfortunately
For expressing a negative experience:
* Badly
* Poorly
* Miserably
The best synonym to use will depend on the specific situation and what you are trying to convey.