* "The depths of despair": This implies a state of utter hopelessness and misery.
* "A stain on humanity": This suggests something that is deeply shameful and morally reprehensible.
* "A wolf in sheep's clothing": This describes someone who appears harmless but is actually dangerous and deceitful.
* "The scum of the earth": This is a highly derogatory and offensive term used to describe someone considered the worst possible type of person.
* "The devil's work": This implies something evil and harmful, often with religious connotations.
Remember, these are just examples. The most negative connotation depends on the specific context and the audience's interpretation.