Similar meaning, less formal:
* Relax
* Chill out
* De-stress
* Kick back
* Let loose
* Unplug
* Take a break
* Slow down
More formal:
* Rejuvenate
* Recuperate
* Rest
* Disengage
* Refocus
Figurative:
* Breathe
* Recharge
* Get away from it all
* Escape the hustle
The best word will depend on the specific context and tone you want to convey.