Poverty-related words:
* Impoverished
* Indigent
* Needy
* Poor
* Penniless
* Bankrupt
Words emphasizing lack:
* Deprived
* Lacking
* Wanting
* Without
Other possibilities:
* Hopeless (in a figurative sense of being without hope)
* Helpless (in the sense of being unable to provide for oneself)
* Miserable (describing the state of being destitute)
It's important to consider the specific context and the nuance you wish to convey when choosing a substitute for "destitute."