General dissatisfaction:
* Dissatisfied
* Unhappy
* Uncontented
* Displeased
* Frustrated
* Resentful
* Grieving
* Agitated
* Annoyed
* Peeved
More negative connotations:
* Bitter
* Grumbling
* Cranky
* Sullen
* Morose
* Incensed
* Furious
* Angry
* Hostile
More specific situations:
* Work: Demoralized, alienated, disillusioned
* Relationships: Hurt, betrayed, offended
The best synonym will depend on the context of your sentence and the specific emotions you want to express.