What are synonyms of the word debilitating?

Here are some synonyms for "debilitating," grouped by their nuance:

General Weakness/Impairment:

* Weakening

* Enervating

* Incapacitating

* Crippling

* Disabling

* Exhausting

* Prostrating

* Draining

Severe or Chronic:

* Withering

* Devitalizing

* Shattering

* Devastating

* Harrowing

Mental/Emotional:

* Overwhelming

* Crushing

* Despairing

* Paralyzing

* Depressing

Specific to Illness/Injury:

* Lamentable (for a physical condition)

* Debilitating (for an illness)

* Enfeeblement (for a weakening condition)

* Ailment (for a minor ailment)

* Affliction (for a serious ailment)

The best synonym for "debilitating" will depend on the specific context and the nature of the weakness or impairment being described.