* Dysphoria: This is a general term for a state of unease, dissatisfaction, or anxiety. It's often associated with feelings of depression or hopelessness.
* Despair: A state of complete hopelessness and dejection.
* Melancholy: A state of pensive sadness, often with a sense of longing or nostalgia.
* Apathy: A lack of interest or enthusiasm, often associated with a feeling of emptiness.
* Anguish: Intense emotional suffering, often accompanied by physical pain.
* Dread: A feeling of apprehension or fear about something that is going to happen.
The best opposite for euphoria really depends on the specific context. For example, if you are talking about the opposite of the *feeling* of euphoria, then dysphoria might be the most accurate. But if you are talking about the opposite of the *state* of euphoria, then something like despair or apathy might be more appropriate.