Medical:
* The doctor carefully examined the patient's jugular vein for signs of infection.
* The paramedic applied pressure to the jugular vein to control bleeding.
Figurative:
* The politician's scathing attack went straight for the jugular, exposing his opponent's weaknesses.
* The company's new advertising campaign aimed to go for the jugular of its competitors.
* The shark went for the jugular of its prey, biting down with incredible force.
Informal:
* "That's just a low blow, man! You went straight for the jugular!"
Note: The word "jugular" is often used figuratively to mean "the weakest point" or "to attack with full force."