Here are some examples:
* ¿De lo que estás hablando? (What are you talking about?)
* No tengo idea de lo que está pasando. (I have no idea what is happening.)
* Me encanta el sabor de lo que cocinaste. (I love the flavor of what you cooked.)
Note: The literal translation of "de lo que" is "of what", but it can also be translated as "about what" depending on the context.