General:
* Job: "What is your job?"
* Work: "I'm looking for work."
* Profession: "She's a doctor by profession."
* Career: "He's trying to advance his career."
More specific:
* Trade: "He learned the trade of carpentry from his father."
* Field: "She's in the medical field."
* Role: "He's filling the role of project manager."
* Position: "The company is hiring for several open positions."
The best common noun to use will depend on what you're trying to communicate. For example, "job" is a more general term, while "profession" implies a higher level of skill and training.