1. As a statement:
* Your sister Theresa, a college student, had a difficult time finding a job. (This clearly identifies Theresa as the subject of the sentence.)
2. As a question:
* Your sister Theresa, a college student, had a difficult time finding a job? (This is asking for confirmation.)
3. As a sentence fragment:
* Your sister Theresa, a college student, had a difficult time finding a job. (This might be used in a casual conversation or a list.)
4. With a more descriptive sentence:
* Your sister Theresa, a college student with a degree in [field of study], had a difficult time finding a job in the competitive [industry] market. (This provides more context and information.)
Important: It's essential to consider the intended meaning and context when choosing punctuation.