General opposites:
* Disable: This is the most direct opposite, meaning to make something incapable of functioning.
* Impair: This means to weaken or damage something, making it less effective.
* Restrict: This means to limit or prevent something from happening.
* Prevent: This means to stop something from happening.
* Hinder: This means to slow down or make something difficult.
* Prohibit: This means to forbid something.
More specific opposites:
* Disable: For a specific function.
* Restrict: For access or use.
* Prohibit: For a specific action.
* Discourage: For an action or behavior.
* Suppress: For emotions or thoughts.
* Control: For power or influence.
Example:
* Enable: The new software enabled the team to work more efficiently.
* Opposite: The lack of funding disabled the team from reaching their full potential.
The best opposite will depend on the specific meaning of "enable" in the context of your sentence.