However, depending on the context, you could use several phrases to convey the same idea:
General:
* Single answer
* One response
* A solitary reply
Specific:
* The only answer (if there is only one correct or possible answer)
* The right answer (if one answer is correct)
* The correct answer (if one answer is correct)
* The best answer (if one answer is considered the most suitable)
The best choice will depend on the specific situation and what you want to emphasize.